STAFF
Personal introduction:
Linghua Zhang, female, professor, Ph.D. supervisor, College of Life Sciences, South China Agricultural University, Provincial Talents Cultivated by “Thousand-Hundred-Ten" Program of Guangdong Province.Since 2006, more than 30 papers have been published in famous international journals such as Vaccine, Molecular Immunology, Developmental and Comparative Immunology, with cumulative impact factor of 118.998 and 8 invention patents authorized. Meanwhile, As the leader of the discipline, she actively promoted the construction of "211" discipline, assisted in organizing and successfully passed the mid-term evaluation of key disciplines of biochemistry and molecular biology in Guangdong Province.In addition, she is also a consultation expert of Guangdong Province in science and technology, an evaluation expert of "postdoctoral fund" of Ministry of Education.
Research Direction:
Microbiology & Immunology
Representative Peer-Reviewed Publications (Since 2007)
（1）Li, J.Q., Fan, Q., Cai, H.M., Deng, J.B., Ming, F.P., Li, J.Y., Zeng, M., Ma, M.P., Zhao, P.J., Liang, Q.Y., Jia, J.H., Zhang, S.X., Zhang L.H.*. (2020). Identification of RBP4 from bighead carp (Hypophthalmichthys nobilis) / silver carp (Hypophthalmichthys molitrix) and effects of CpG ODN on RBP4 expression under A. hydrophila challenge. Fish & Shellfish Immunology https://doi.org/10.1016/j.fsi.2020.03.036. (Q1, *Corresponding author, 2019 SCI Impact factor, 3.298)
（2）Cai, H.M., Wei, J.T., Shen, H.K., Li, J.Y., Fan, Q., Zhao, Z.Z., Deng, J.B., Ming, F.P., Zeng, M., Ma, M.P., Zhao, P.J., Liang, Q.Y., Jia, J.H., Zhang, S.X., Zhang L.H.*. (2020). Molecular cloning, characterization and expression profiles of Annexin family (ANXA1~A6) in yellow catfish (Pelteobagrus fulvidraco) and ANX regulation by CpG ODN responding to bacterial infection. Fish & Shellfish Immunology 99, 609-630. (Q1, *Corresponding author, 2019 SCI Impact factor, 3.298)
（3）Deng J.B., Li J.Q., Ma M.P., Zhao P.J., Ming F.P., Lu, Z.P., Shi J.Q., Fan Q, Liang Q.Y.,
Jia J.H., Li J.Y., Zhang S.X., Zhang L.H.*. （2020）Co-expressing GroEL-GroES, Ssa1-Sis1 and Bip-PDI chaperones for enhanced intracellular production and partial-wall breaking improved stability of porcine growth hormone. Microb Cell Fact. 19,35. (Q1, *Corresponding author, 2019 SCI Impact factor, 4.402)
（3）Zhang S.X., Wu L., Chen J.W., Wei J.T., Cai H.M., Ma M.P., Zhao P.J., Ming F.P., Jia J.H., Li J.Y., Fan Q., Liang Q.Y., Deng J.B., Zeng M., Zhang L.H.*. (2019) Effects of porcine IL-17B and IL-17E against intestinal pathogenic microorganism. Molecular Immunology.116:151-159(*Corresponding author, 2018 SCI Impact factor,3.064)
（4）Zhang S.X, Cai H.M., Cao D, Deng J.B., Jia J.H., Li J.Q., Ming F.P., Zhao P.J., Ma M.P., Liang Q.L., Zeng M., Zhang L.H.*. (2019) Recombinant plasmids containing CpG with porcine host defense peptides (PR-39/pBD-1) modulates the innate and adaptive intestinal immune responses (including maternal-derived) in piglets. Int. Immunopharmacol. 70, 467-476 (*Corresponding author, 2018 SCI Impact factor, 3.361)
（5）Cai H.M., Deng J.B., Li J.Q., Ma M.P., Huang C, Zhao P, Ming F.P., Liang Q.Y., Jia J.H., Zhang S.X., Zeng M., Zhang, L.H.*. (2019) Modulating the 3’ end-DNA and the fermentation process for enhanced production and biological activity of porcine interferon-gamma. PLoS ONE 14(3), e0214319. (*Corresponding author, 2018 SCI Impact factor, 2.766)
（6）Yang, J., Cai, H.M., Liu, J., Z, Zeng. M., Cheng, Q.M, Zhang, L.H.*. (2018) Controlling AOX1 promoter strength in Pichia pastoris by manipulating poly (dA:dT) tracts. Scientific Reports, 8:1401-1412.（*Corresponding author, 2018 SCI Impact factor, 4.602）
（7）Cai, H.M., Chen, J.W., Liu, J., Ming, F.P., Lu, Z.P., Cheng, Q.M., Yang, J., Zhang, L.H.*.(2017) CRIP1, a novel immune-related protein, activated by Enterococcus faecalis in porcine gastrointestinal epithelial cells. Gene, 598, 84-96. (*Corresponding author, 2016 SCI Impact factor, 2.339)
（8）Yang, J., Lu, Z.P., Chen, J.W., Chu, P.P., Cheng, Q.M., Liu, J., Ming, F.P., Huang, C.Y., Xiao, A.J., Cai, H.M., Zhang, L.H.*. (2016) Effect of cooperation of chaperones and gene dosage on the expression of porcine PGLYRP-1 in Pichia pastoris. Applied Microbiology and Biotechnology, 100:5453–5465.(*Corresponding author, 2015 SCI Impact factor, 3.811)
（9）Cai, H.M., Kuang Z.S., Huang K.Y., Shi, J.Q., Zhao X.J., Chu, P.P., Huang, C.Y., Ming, F.P., Xia, F.G., Yang, J., Zhang, L.H.*. (2014) CpG oligodeoxynucleotide protect neonatal piglets from challenge with the enterotoxigenic E. coli, Veterinary Immunology and Immunopathology, 161, 66–76 (*Corresponding author, 2013 SCI Impact factor, 1.782)
（10）Ming, F.P., Yang, J., Chu, P.P., Ma, M.P., Shi, J.Q., Cai, H.M., Li, H.Z., Jiang, Z.G., Wang, W.F., Zhang, S.Q., Zhang, L.H.*. (2013) Immunization of Aged Pigs with Attenuated Pseudorabies Virus Vaccine Combined with CpG Oligodeoxynucleotide Restores Defective Th1 Immune Responses, PLOS ONE, 8(6), 65536-65536 (*Corresponding author, 2013 SCI Impact factor, 4.092)
（11）Ma, M.P., Wang, L.L., Yang, J., Cai, H.M., Shi, J.Q., Huang, Z.F., Zhang, S.Q., Zhang, L.H.*. (2012) Age-related impaired Th1 responses to PRV vaccine in vivo in aged pigs, Molecular Immunology, 52, 217-222 (*Corresponding author, 2011 SCI Impact factor, 2.897)
（12）Yang, J., Mao, M.P., Huang Z.F., Zhang, S.Q., Chen, S.F., Li, H.Z., Jiang, Z.G., Cao, G.J., Cao, D., Wang, X.F., Zhang, L.H.*. (2012) Innate defence regulator peptide synergizes with CpG ODN for enhanced innate instestinal immune responses in neonate piglets. Int. Immunopharmacol. 12(2), 415–424 (*Corresponding author, 2011 SCI Impact factor,2.325)
（13）Cao, D., Li, H.Z., Jiang, Z.G, Cheng, Q., Yang, Z.H., Xu, C.C., Cao, G.J.,Zhang, L.H.*. (2011) CpG oligodeoxynucleotide synergizes innate defense regulator peptide for enhancing the systemic and mucosal immune responses to pseudorabies attenuated virus vaccine in piglets in vivo. Int. Immunopharmacol. 11, 748–754 (*Corresponding author, 2010 SCI Impact factor,2.325)
（14） Cao, D., Li, H.Z., Jiang, Z.G, Xu, C.C., Cheng, Q., Yang, Z.H., Cao, G.J., Zhang, L.H.*. (2010) Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets. Vaccine. 28, 6006–6013. (*Corresponding author, 2009 SCI Impact factor, 3.616)
（15）Cheng, Q., Xu, C.C., Zhang, L.H.*., Li, J.Q., Cao, T., Zhang, M.R. (2010) Administered CpG Oligodeoxynucleotide Induces mRNA expression of CXC and CC Chemokines at the Intestinal Mucosa and PBMCs in Piglets. Int. Immunopharmacol. 10, 611-618 (*Corresponding author, 2009 SCI Impact factor, 2.214)
（16）Cheng, Q., Jiang, Z.G., Xu, C.C., Li, H.Z., Cao, D., Yang, Z.H., Cao, G.J., Zhang, L.H.*.(2010) CpG oligodeoxynucleotide promotes protective immunity in the enteric mucosa and suppresses enterotoxigenic E. coli in the weaning piglets. Int. Immunopharmacol. 
10, 1249–1260 (*Corresponding author, 2009 SCI Impact factor, 2.214)
（17）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2008a) In vivo oral administration effects of variousoligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to pseudorabies attenuated virus vaccine in newborn piglets. Vaccine. 26, 224-233. (*Corresponding author, 2007 SCI Impact factor, 3.377)
（18）Zhang, L.H.*., Zhang, M.R., Li, J.Q., Cao, T., Tian, X.S., Zhou, F.Z. (2008b) Enhancement of mucosal immune responses by intranasal co-delivery of Newcastle disease vaccine plus CpG oligonucleotide in SPF chickens in vivo. Research in Veterinary Science. 85, 495–502. (*Corresponding author, 2007 SCI Impact factor, 1.274)
（19）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2007a) In vivo immunostimulatory effects of CpG ODN in newborn piglets. Molecular Immunology. 44, 1238–1244. (*Corresponding author, 2006 SCI Impact factor, 4.768)
（20）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2007b) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in the immune response to swine streptococcic septicemia vaccine in weaned piglets. Molecular Immunology. 44, 1141–1149. (*Corresponding author, 2006 SCI Impact factor, 4.768)
（21）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2007c) Vaccination with porcine reproductive and respiratory syndrome killed virus vaccine and immunostimulatory oligodeoxynucleotides induces specific immunity in piglets. Vaccine. 25, 1735–1742. (*Corresponding author, 2006 SCI Impact factor, 3.159)
（22）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2007d) Vaccination with Newcastle disease vaccine and CpG oligodeoxynucleotides induces specific immunity and protection against Newcastle disease virus in SPF chicken. Veterinary Immunology and Immunopathology. 115, 216–222. (*Corresponding author, 2006 SCI Impact factor, 1.994)
（23）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2007e) Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo. International Immunopharmacology. 7(13), 1732–1740. （*Corresponding author, 2006 SCI Impact factor, 2.157）
（24）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2007f) CpG oligodeoxynucleotides augment the immune responses of piglets to swine Pasteurella multocida living vaccine in vivo. Research in Veterinary Science. 83(2),171-181. (*Corresponding author, 2006 SCI Impact factor, 1.258)
（25）Zhang, L.H.*., Guo, Y., Tian, X.S., Zhou, F.Z. (2006a) Co-administration of porcine-specific CpG oligodeoxynucleotide enhances the immune responses to pseudorabies attenuated virus vaccine in newborn piglets in vivo. Developmental and Comparative Immunology. 30(6), 589-596. (*Corresponding author, 2005 SCI Impact factor, 3.261)
（26）Zhang, L.H.*., Tian, X.S., Guo, Y., Zhou, F.Z. (2006b) Effects of CpG ODN on CD4+ and CD8+ T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine. Vaccine. 24(11), 1874-1879. (*Corresponding author, 2005 SCI Impact factor, 2.822)
（27）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2006c) The efficacy of CpG oligodinucleotides, in combination with conventional adjuvants, as immunological adjuvants to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(8), 1267-1276. (*Corresponding author, 2005 SCI Impact factor, 2.008)
（28）Zhang, L.H.*., Tian, X.S., Zhou, F.Z. (2006d) In vivo effects of oligodeoxynucleotides containing synthetic immunostimulatory motifs in weaned piglets. International Immunopharmacology. 6(10),1623-1631. (*Corresponding author, 2005 SCI Impact factor, 2.008)
（29）Zhang, L.H.*., Guo, Y., Tian, X.S., Zhou, F.Z. (2006e) CpG oligodinucleotides induce strong humoral and cellular responses to swine streptococcic septicemia vaccine in piglets in vivo. International Immunopharmacology. 6(3), 342-350. (*Corresponding author, 2005 SCI Impact factor, 2.008)
（30）Zhang, L.H.*., Tian, X.S., Guo, Y., Zhou, F.Z. (2006f) The effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of the newborn piglets inoculated with pseudorabies attenuated vaccine. Research in Veterinary Science. 80, 281-286. (*Corresponding author, 2005 SCI Impact factor, 1.106)
Related patents:
（1）Zhang, L.H., Tian, X.S., Kuang, Z.S., Li, W., Li, J.X., “Pretreatment technology of beneficial microorganism preparation stabilizatio” ，2006.12, China, ZL200310117512.8
（2）Kuang, Z.S., Tian, X.S., Zhang, L.H., Li, W., Li, J.X., “Post treatment technology of beneficial microorganism preparation stabilization”, 2006.8, China, ZL200310117511.3
（3）Kuang, Z.S., Zhang, L.H., Xu, Z.H., “A method of microbial transformation of pineapple dregs into biological feed”, 2008.1, China, ZL200610033024.2
（4）Zhang, L.H., Li, H.Z., Jiang, Z.G., “An efficient CpG preparation and its preparation and Application”, 2014.6, China，ZL201210090979.7
（5）Zhang, L.H., Kuang, Z.S., Cai, H.M., Zhao, X.J., Chu, P.P., Ye, M.Q., “An efficient method to improve the germination rate of Bacillus subtilis”, ZL201410162370.5
（6）Zhang, L.H., Cai, H.M., Ma, M.P., Zhou, J.A. “A highly effective anti-inflammatory Pb ODN sequence and its application”, ZL 20151043403.5
（7）Zhang, L.H., Ma, M.P., Yang, J., “A mixed fermentation method of Lactobacillus acidophilus and Acetobacter” ，ZL201510335715.7
（8）Jiang, X.B., Zhang, L.H., Hu, W.B., Ma, M.P., Huang, H.W., “A culture medium of Rhodopseudomonas palustris with high efficiency to reduce COD in water” ZL201610026084.5
Project undertaken:
（1）“Transverse” research project, Development and application demonstration of a novel schizophyllin-toll5 activator nanobiomaterial, 2019/10-2022/10, 2 million yuan, in research, principal investigator.
（2）Guangzhou key scientific and technological projects , Development and application of a new type of plectasin secretion probiotics to control Streptococcosis of Tilapia, 2019/01-2022/12, 450000 yuan, in research, principal investigator.
（3）Guangdong Natural Science Foundation free application project,Study on the mechanism of CRIP1 controlling salmonella infection in pig intestine by regulating the level of Zn2+、 2018/01-2021/12, 100000 yuan, in research, principal investigator.
（4）Guangzhou key scientific and technological projects , Development and application of 3-OH PAME quenching enzyme secretory high efficiency bacterial wilt compound biocontrol agent, 2018/01-2021/12, 450000 yuan, in research, principal investigator.
（5）Guangdong Natural Science Foundation free application project, Establishment of cell model of HPS infection and Study on the mechanism of new sup ODN against HPS infection, 2015/01-2017/12, 100000 yuan, in research, principal investigator.
（6）Major specialized project of collaborative innovation of industry, University and research in Guangzhou, Study on the prevention and treatment of piglet diarrhea by probiotics litchi polyphenols, 2016/01-2019/12, 1 million yuan, in research, Co-principal investigator.
（7）2012.1-2014.12 Presided over the joint project of production, education and research of the Ministry of education of Guangdong Province "Research and application of production of feed antimicrobial peptide pr39 by fermentation of secretory Pichia pastoris" (300000 yuan, NO: 2011B090300020, finished）
（8）2011.1-2013.12 Presided over NSFC "molecular mechanism of CpG ODN delaying T cell aging through NF - κ B signal system"（340000 yuan, NO: 31072114, finished）
（9）2010.1-2012.12 Presided over Guangzhou Key scientific and technological projects "Research and demonstration on the key technology of CpG preparation against weaning stress diarrhea of piglets"（150000 yuan，NO: 2010Z1-E311,finished）
（10）2009.9-2012.9 Presided over Guangdong Province key agricultural projects "Study and application of CpG as an immunosynergist of swine high fever vaccine"（50000 yuan，NO: 2009B020307010, finished）
（11）2008.8-2010.12 Presided over the US Merial cooperation project "study on the mechanism of disease resistance and immunity of CpG piglets"（240000 yuan, finished）
（12）2008.1-2010.12 Presided over Guangzhou Key scientific and technological projects "Construction of efficient functional nitrate degrading bacteria and production and application of its preparation", （120000 yuan, NO: 2008-Z1
E081, finished）
（13）2007.10-2008.9 Presided over the US Merial cooperation project "CpG induced innate immunity in piglets"（513000 yuan, finished）
（14）2006.9-2009.8 Presided over Guangdong Province key agricultural projects "Construction and application of high efficient nitrate degradation functional flora"（60000 yuan, NO: 2006B20601011, finished）
（1）Tian, X.S., Zhang, L.H., Shi, H.R., Kuang, Z.S., Li, J.S., Ke, H., Pan, M.S., Tang, X.J., Ma, J.Y., Chen, W., Huang, X.G., Xie, H.Y., Zhou, F.Z., Li, G.L., Sun, X.G., "Research and application of beneficial microbial agents to promote animal growth", Won the second prize of Guangdong science and technology progress in 2005.
（2）Tian, X.S., Shi, H.R., Zhang, L.H., Zhang, B., Kuang, Z.S., Tang, X.J., Ke, H., Li, J.S., Ma, J.Y., Zhou F.Z., Chen, W., "Research and application of ecological culture technology of prawn", won the third prize of scientific and technological progress of Maoming City in 2005.